3.3. Risk Products

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Both Body mass index and you may lbs was in fact correlated that have BMD, and you may BMC indications as well as the most effective Pearson’s relationship coefficients was basically located ranging from lbs and BMC altogether stylish and you may trochanter countries and this new weakest ones was basically between Bmi and you can femoral neck BMC. Brand new correlations anywhere between ages and BMD and you will BMC evidence had been negative (Dining table 4).

Age-modified ratio of BMD and BMC variation explained because of the Body mass index and you will weight is actually shown inside Dining table 5. Pounds had a tendency to let you know greater differences in BMD and you will BMC distribution at all new learnt skeletal sites as compared to Body mass index. This was reflected by steeper mountain (?) of particular linear regression contours. Ideal difference in BMD and you will BMC shipment looked at the trochanter BMC followed by lumbar BMC to own lbs. Weight is a vital predictor out-of BMD and you will BMC version in the earlier Iranian boys.

4. Talk

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The fresh mechanisms wherein fatty tissue exerts results toward BMD reputation commonly completely obvious. This new putative process relevance away from adipose tissue getting skeletal integrity most likely resides in the new part of numerous adipokines into the bone restorations as a result of impact on one another development and you can resorption. Has just, limbs has been considered an enthusiastic hormonal organ affecting body weight handle and you will sugar homoeostasis from the steps out of limbs-derived issues instance osteocalcin and you may osteopontin [23, 34–36]. The newest putative crosstalk ranging from weight and bones comprises a good homoeostatic views system where adipokines and you will particles produced from the osteoblasts and you may osteoclasts represent the web link off a dynamic limbs-adipose axis [34–36]. Being obese is additionally for the BMD by the transformation off androgen in order to estrogen , and therefore improves bone mass both in men [38, 39] and you can holds fit plasma amounts of insulin and you can regulating factors and insulin-such as for instance increases basis-step 1, leptin, and you will adiponectin . Likewise, obesity provides padding on the stylish in case there are an effective slip . not, the new elements in which many of these events occur are still uncertain.